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e., Web) and serotonin (i.e, SERT). Mephedrone and methylone act as non-selective transporter substrates, thus stimulating non-exocytotic release of dopamine, norepinephrine and serotonin. Against this, MDPV functions for a strong blocker at DAT and Web, with minimal impact at SERT. Administration of mephedrone or methylone to rats improves extrace